I see a few of my favorites have been mentioned already (Aeon’s End, Spirit Island, The Crew, Pandemic Legacy) but here’s a few more:
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Gloomhaven: There’s a reason this game was at the Boardgamegeek #1 spot for years. Absolutely an epic game, with so much strategy and variety involved. For those who are intimidated by the complexity, size or price of the game, there is also Gloomhaven: Jaws of the Lion, which is essentially a light version of the game. An excellent starting point, and not any less fun than it’s big sibling.
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Oathsworn: Into the Deepwood: Another big campaign game with very interesting mechanics. The game is quite hard and punishing, but you have lots of difficulty levels you can play on. The story is set in a land overrun by the Deepwood, a forest filled with huge monsters. You play a band of mercenaries who defend people from those monsters.
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Sprawlopolis: A game consisting of 18 cards, that contain city blocks and roads, and each player places a card down to add to the city. Each card has a different scoring system on its back, and you draw a few for each game, so every game feels entirely different. Quick to play, and fits in your pocket so you can bring it anywhere.
Not OP, but Spirit Island is one of my favourite games too. I think it’s great at most player counts, but I like it the most at 2p. You can help each other out, fill in each other’s weak spots, but it doesn’t get as overwhelming as at larger player counts. And yes indeed, the decision space in Spirit Island is so big that alpha gaming is not easy (once you’ve played it a lot that gets easier, though), which makes it a great actual co-op game.